©2017 BY INTERCLINICAL LABORATORIES.

New Product Focus: Molyzinc



This advanced mineral supplement contains molybdenum as the principal mineral, supported by zinc (fully reacted amino acid chelate), plus synergistic nutrients vitamin C (ascorbic acid) and activated vitamin B6.

Molybdenum is an essential component of several metalloenzymes including xanthine oxidoreductase, sulphite oxidase, aldehyde oxidase andmitochondrial amidoxime.

Molybdenum plays a pivotal role in normal sulphur amino acid metabolism where it acts as a cofactor in the catalysation of sulphite to sulphate. This reaction is essential for the metabolism of the sulphur-containing amino acids methionine and cysteine. These amino acids play immensely important roles in the methylation and transsulphuration pathways.

Zinc is a key component in over 200 enzymes. In one of these enzymatic reactions zinc appears to facilitate the function of the enzyme crARC, a cofactor of the molybdenum-dependent enzyme sulphite oxidase. In this way zinc may act as a molybdenum synergist, assisting its catalytic activity.(1)

Vitamin B6 and molybdenum each play unique but complementary roles in the metabolism of important sulphur-containing amino acids. Vitamin B6 is a cofactor in several amino acid enzymatic reactions. These reactions are necessary precedents to the molybdenum-containing enzyme sulphite oxidase's reduction of sulphite to the safer compound sulphate.(2)

Vitamin C has a critical function in reducing metals into their appropriate oxidation state needed for efficient ion transport across the intestinal border. In this way, in vitro studies suggest that Vitamin C may help faciltate efficient uptake of molybdenum.(3,4,5)

MolyZinc can be prescribed in cases where dietary molybdenum intake is inadequate

References

1. Chamizo-Ampudia A, Galvan A, Fernandez E, Llamas A. The Chlamydomonas reinhardtii molybdenum cofactor

enzyme crARC has a Zn-dependent activity and protein partners similar to those of its human homologue.

Eukaryotic cell. 2011 Oct 1;10(10):1270-82.

2. Poloni S, Blom HJ, Schwartz IV. Stearoyl-CoA Desaturase-1: is it the link between sulfur amino acids and lipid

metabolism?. Biology. 2015 Jun 3;4(2):383-96

3. Garrick MD, Dolan KG, Horbinski C, Ghio AJ, Higgins D, Porubcin M, Moore EG, Hainsworth LN, Umbreit JN,

Conrad ME, Feng L. DMT1: a mammalian transporter for multiple metals. Biometals. 2003 Mar 1;16(1):41-54.

4. Conrad ME, Umbreit JN, Moore EG, et al. Separate pathways mechanisms and adaptations. 4th ed. New York: WH Freeman for cellular uptake of ferric and ferrous ion. Am J Physiol and Company, 2001 Gastrointestinal Liver

Physiol 2000; 279: G767-74

5. Russell MS, Bailey J, Duffy SJ, Vogels CM, Broderick TL, Westcott SA. Gut transport of a molybdenum/ascorbic

acid complex. Drugs in R&D. 2006 Mar 1;7(2):111-7.


23 views